I've just switched a site onto a domain I own and added the CNAME lines to the zone files. According to this site, the changes have propagated to all DNS servers. But when I try to access the site (either by the domain I own or by webapp-XXXX.pythonanywhere.com) it just shows a page saying "Coming soon. This is going to be another great site hosted by PythonAnywhere...". A possible cause of this problem is that I initially misconfigured the CNAME lines (to be webapp-XXX.pythonanywhere.com.mydomain.co.uk), but the correct CNAMEs have now propagated so I don't see why that could be an issue. If relevant, the URL is www.roddymacsween.co.uk and I registered it with Gandi. The CNAME is webapp-244945.pythonanywhere.com .