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Anything change for MySQL lately?

Just wondering if anything changed regarding MySQL lately? Just noticed my site has been down for several days, and will not come up.

Error log is full of: sqlalchemy.exc.OperationalError: (_mysql_exceptions.OperationalError) (2003, "Can't connect to MySQL server on '0.0.0.0' (111)")

I didn't change anything, so wondering if anyone else has seen this problem & knows where I could start looking? The "start a console" link worked from the database tab, so I know the DB is up.

Have you updated your hostname, see e.g. https://www.pythonanywhere.com/forums/topic/4058/ ?